As of July 2026, Painkiller Jane Season 1 aired in 2007 with 22 episodes — streaming now on The CW. Full episode guide and where to watch below.
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Painkiller Jane Season 1

2007 22 Episodes Sci-Fi & Fantasy · Action & Adventure ⭐ 6/10

Painkiller Jane Season 1 has built a real following on among viewers who want their sci-fi to think as hard as it looks. A single, tightly-focused season means there is plenty to get through without ever feeling padded. 53 people have weighed in on TMDB, and the verdict leans heavily positive. Kristanna Loken sets the tone, and the world-building does the rest. Put it on tonight and see for yourself.

Part of the current wave of titles people are actually watching, Painkiller Jane Season 1 earns its spot. What makes Painkiller Jane Season 1 work is that the ideas never crowd out the people having them. Season 1 of Painkiller Jane includes 22 episodes. It aired from April 2007 to September 2007. This season stars Kristanna Loken, Rob Stewart and Noah Dalton Danby. Kristanna Loken and Rob Stewart lead a cast that brings real weight to the material. It was aired in 2007. What separates Painkiller Jane Season 1 from lesser genre entertainment is a willingness to let the concept cost the characters something. It knows exactly what it is, and does not try to be anything else.

For late-night viewing or a proper weekend binge, Painkiller Jane Season 1 fits the bill. It rewards viewers regardless of what else is in their watch history. The complete run is available and best experienced without too much prior knowledge of where it goes. Kristanna Loken's performance is the anchor the more ambitious moments need. The world-building pays off in ways you will not anticipate on a first watch.

📡 Where to Watch Painkiller Jane Season 1

🇺🇸 United States
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🎬 Painkiller Jane Season 1 — Episode Guide

E1
Pilot
2007-04-13
Jane Vasco with the help of a new covert government unit must track down and contain the spread of "Neuros," genetically altered humans with extraordinary powers.
E2
Toy Soldiers
2007-04-20
When military stockpiles start to go missing before a presidential visit, Jane and the team are forced into high alert. Meanwhile, Jane confronts a Neuro with the ability to control the dead.
E3
Piece of Mind
2007-04-27
A Neuro with the ability to steal memory and knowledge preys on Riley putting the security of the entire operation in jeopardy.
E4
Catch Me if You Can
2007-05-04
A Neuro who can see the future warns Jane and the team of their impending death on the day they arrest him. Meanwhile, the team is disturbed by the psychic's purchases
E5
Nothing To Fear But Fear Itself
2007-05-11
When inhabitants of an FBI safe house start to experience unexplained dreams and visions, Jane and crew must investigate potential Neuro activity.
E6
Breakdown
2007-05-18
While investigating psychiatric patients who share the same unusual nightmare, Jane and Maureen suspect a Neuro has the ability to use nightmares as weapons.
E7
Higher Court
2007-06-01
The team investigate the suicides of individuals placed in witness protection and discover a Neuro who is capable of creating hallucinations.
E8
Friendly Fire
2007-06-08
Awakening in a hospital Jane learns that she murdered Riley. Meanwhile, Maureen investigates a doctor researching Neuros.
E9
Trial by Fire
2007-06-15
Connor is arrested for arson and murder while out hunting for a Neuro, which is believed to have started numerous house fires.
E10
Portraits of Lauren Gray
2007-06-22
A young woman suddenly ages overnight, Jane and Maureen go undercover to find the cause.
E11
Ghost in the Machine
2007-06-29
Connor suffers a series of unfortunate events, believing it to be coincidental. However, he learns that members of his former police squad have died of strange causes.
E12
Something Nasty in the Neighborhood
2007-07-06
Jane and Connor go undercover in a small town, posed as a married couple, after a federal agent's disappearance prompts an investigation.
E13
The League
2007-07-13
An investigation is started after Neuros begin to die before the team can apprehend them.
E14
The Amazing Howie
2007-07-20
Howie is a magician who can miraculously perform the impossible, which prompts Riley to begin an investigation into possible Neuro activity.
E15
The Healer
2007-07-27
Sabotage hinders Jane's efforts to catch a Neuro, she becomes suspicious of a faith healer that she has been visiting.
E16
Thanks For the Memories
2007-08-03
Jane seeks help from a Neuro after Brian (Jane's boyfriend) and Joe forget who she is, the Neuro has the ability to remove and store memories within his mind.
E17
Playback
2007-08-17
A Neuro causes the team to become stuck in a timeloop, causing them to relive the same day repeatedly. Meanwhile, the Neuro who caused the timeloop tries to finish an assassination.
E18
Jane 113
2007-08-24
Jane discovers the disturbing truth about her abilities while searching for a Neuro who escaped the team.
E19
What Lies Beneath
2007-08-31
The team respond when several incarcerated Neuros revolt and launch a prison break.
E20
The Beast of Bolnar
2007-09-07
The residents of a small village are plagued by an invisible presence which is attacking and murdering the villagers.

🎭 Cast of Painkiller Jane Season 1

Kristanna Loken
Kristanna Loken
Jane Vasco
Rob Stewart
Rob Stewart
Andre McBride
Noah Dalton Danby
Noah Dalton Danby
Connor King
Stephen Lobo
Stephen Lobo
Seth Carpenter
Sean Owen Roberts
Sean Owen Roberts
Riley Jensen

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